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. 2023 Oct 4;16:1144614. doi: 10.3389/fnmol.2023.1144614

Figure 5.

Figure 5

Co-incubation with INCB3344 or SQ22536 eliminated increased Ih current caused by CCL2 in small diameter DRG neurons. (A,D) Representative traces of Ih recorded in small DRG neurons in response to hyperpolarizing voltage steps of −60 to −120 mV in 10 mV increments from a holding potential at −60 mV in both in control and 5 h incubation with CCL2 and INCB3344 (10 nM) (A) or CCL2 and SQ22536 (50 μM) (D). (B) Current–voltage relationship of Ih in small DRG neurons from control and 5 h after incubation with CCL2 and INCB3344 (10 nM) (B, n = 8–12) or CCL2 and SQ22536 (50 μM) (E, n = 8–12) (by two-way ANOVA, Fisher’s LSD test). (C) Ih density in small DRG neurons from control and 5 h incubation with CCL2 and INCB3344 (10 nM) (C, n = 8–12) or CCL2 and SQ22536 (50 μM) (F, n = 8–12) (by nonparametric Mann–Whitney test). All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.