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. 2023 Sep 28;31(11):101803. doi: 10.1016/j.jsps.2023.101803

Table 2.

In vitro EGFR-2, and Her-2 inhibitory effects of the synthesized compounds 5a, 5b and 5 g.

Comp. No. IC50 (µM)a
EGFR
Inhibition
Her2
Inhibition
5a 0.116 ± 0.005 0.055 ± 0.003
5b 0.132 ± 0.006 0.21 ± 0.01
5 g 0.077 ± 0.004 0.085 ± 0.004
Erlotinib 0.09 ± 1.65 0.038 ± 0.002
Gefitinib 0.052 ± 0.78 0.072 ± 0.98
a

IC50 value is the compound concentration required to produce 50% inhibition.