Table 1.

IC₅₀ values for inhibition of CypD PPIase activity by C31 derivatives

Compound	CypD PPIase activity IC50 (μM)
CsA	0.02 ± 0003
ALV	0.03 ± 0.005
C31	0.20 ± 0.10
C32	1.18 ± 0.43
C71	0.79 ± 0.21
C90	0.32 ± 0.16
C99	0.63 ± 0.49
C101	0.40 ± 0.19
C104	0.22 ± 0.06
C105	0.35 ± 0.16
C106	1.26 ± 0.11
C107	0.17 ± 0.05
C108	0.48 ± 0.23
C110	0.10 ± 0.02
C112	0.48 ± 0.04
C115	0.50 ± 0.32
C119	0.15 ± 0.03
C120	0.15 ± 0.05
C123	1.26 ± 0.37
C129	0.26 ± 0.07
C131	0.48 ± 0.12
C142	0.42 ± 0.10
C143	0.72 ± 0.21
C144	0.31 ± 0.16
C170	1.05 ± 0.72
C171	0.34 ± 0.13
C172	0.21 ± 0.07
C173	0.65 ± 0.14
C177	0.49 ± 0.32
C178	0.40 ± 0.19
C179	0.28 ± 0.06
C182	0.16 ± 0.03
C183	0.26 ± 0.13
C185	0.59 ± 0.19

ALV, alisporivir; CsA, cyclosporin A; CypD, cyclophilin D; PPIase, peptidyl-prolyl cis-trans isomerase.