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Kinetic parameters for wild-type and mutant β-lactamases for inhibitors assayed with carbenicillina
| β-Lactamase | TZB
|
CLV
|
SLB
|
|||
|---|---|---|---|---|---|---|
| Ki (μM) | Relative valueb | Ki (μM) | Relative value | Ki (μM) | Relative value | |
| PSE-4 (wild type) | 0.33 ± 0.06 | 1 | 22 ± 3 | 1 | 6 ± 0.9 | 1 |
| PSE-4 mutant (216VTG→SAR) | 10 ± 1.2 | 30 | 32 ± 4 | 1.45 | 222 ± 4 | 37 |
Abbreviations: TZB, tazobactam; SLB, sulbactam; CLV, clavulanic acid.
Ratio of Ki for the mutant relative to that for the wild type.
