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Kinetic characteristics for the inactivation chemistry of the PSE-4 β-lactamase
| β-Lactamase | Clavulanate
|
Tazobactam
|
||||
|---|---|---|---|---|---|---|
| kcat (s−1) | kinact (s−1) | kcat/kinact | kcat (s−1) | kinact (s−1) | kcat/kinact | |
| PSE-4 (wild type) | 72 | 0.90 | 80 | 1,030 | 1.03 | 1,000 |
| PSE-4 mutant (216VTG→SAR) | 58 | 0.73 | 80 | 221 | 0.88 | 250 |
