Table 1.
Summary of baseline characteristics of N = 180 women initiating PrEP and enrolled in a single arm trial of a safer conception intervention for HIV prevention in Durban, South Africa 2017–2020, overall and by adherence trajectory group.
| Characteristics (n with available data) | Adherence trajectory groupa | ||||
|---|---|---|---|---|---|
| Overall N = 180 | 1: High steady adherence N = 40 (22%) | 2: Moderate but steady adherence N = 55 (31%) | 3: Consistently declining adherence N = 38 (21%) | 4: Rapidly declining adherence then rebound N = 47 (26%) | |
| Age (years) (n = 180) | |||||
| Mean | 24.8 | 25.8 | 25.1 | 24.8 | 23.5 |
| Median (25th, 75th percentile) | 24.4 (21.7, 27.2) |
25.5 (23.1, 29.1) |
24.9 (22.8, 26.7) |
24.4 (20.9, 27.8) |
22.3 (20.7, 25.8) |
| Education (n = 180) | |||||
| Grade 7–11 | 28 (16%) | 7 (18%) | 7 (13%) | 8 (21%) | 6 (13%) |
| Grade 12 or beyond | 152 (84%) | 33 (83%) | 48 (87%) | 30 (79%) | 41 (87%) |
| Currently employed (n = 180) | 46 (25%) | 16 (40%) | 15 (27%) | 7 (18%) | 8 (17%) |
| Income, per month (n = 131)b | |||||
| <$116 | 48 (36%) | 9 (32%) | 12 (31%) | 11 (41%) | 16 (42%) |
| $116-$232 | 41 (31%) | 11 (39%) | 12 (31%) | 8 (30%) | 10 (26%) |
| >$232 | 42 (32%) | 8 (28%) | 14 (37%) | 8 (30%) | 12 (31%) |
| Prior pregnancies (n = 180) | |||||
| 0 | 70 (39%) | 16 (40%) | 17 (31%) | 17 (45%) | 20 (42%) |
| 1 | 71 (39%) | 13 (32%) | 23 (42%) | 13 (34%) | 22 (47%) |
| 2+ | 39 (22%) | 1 (27%) | 15 (27%) | 8 (21%) | 5 (11%) |
| Sexual partners, past 3 months (n = 179) | |||||
| 1 | 156 (87%) | 39 (97%) | 43 (80%) | 36 (95%) | 38 (81%) |
| 2+ | 23 (13%) | 1 (2%) | 11 (20%) | 2 (5%) | 9 (19%) |
| HIV serostatus of pregnancy partner (n = 179) | |||||
| Known to be HIV negative | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Known to be HIV positive | 7 (4%) | 6 (15%) | 0 (0%) | 1 (3%) | 0 (0%) |
| Unknown HIV serostatus | 172 (96%) | 34 (85%) | 54 (100%) | 37 (97%) | 47 (100%) |
| Relationship status with pregnancy partner (n = 179) | |||||
| Ongoing casual partner/one-time encounter | 2 (1%) | 0 (0%) | 1 (2%) | 0 (0%) | 1 (2%) |
| Boyfriend/main partner for <6 months | 6 (3%) | 2 (5%) | 0 (0%) | 2 (5%) | 2 (4%) |
| Boyfriend/main partner for ≥6 months | 164 (92%) | 36 (90%) | 51 (94%) | 35 (92%) | 42 (89%) |
| Spouse or living as married ≥6 months | 7 (4%) | 2 (5%) | 2 (4%) | 1 (3%) | 2 (4%) |
| Any alcohol consumption, past year (n = 179) | 93 (52%) | 17 (42%) | 33 (61%) | 18 (47%) | 25 (53%) |
| Depression score ≥ 1.75 (n = 177)c | 9 (5%) | 2 (5%) | 5 (9%) | 1 (3%) | 1 (2%) |
| Sexual Relationship Power Score (n = 156)d | |||||
| Mean | 2.6 | 2.6 | 2.6 | 2.6 | 2.6 |
| Median (25th, 75th percentile) | 2.6 (2.4, 2.8) | 2.7 (2.5, 2.9) | 2.6 (2.4, 2.8) | 2.6 (2.5, 2.8) | 2.6 (2.3, 2.8) |
| Perceived HIV risk (n = 170)e | |||||
| Mean | 19.7 | 20 | 20 | 19.7 | 19.1 |
| Median (25th, 75th percentile) | 20 (18, 22) | 20 (18, 23) | 21 (18, 21) | 19.5 (18, 21) | 19 (17.5, 21) |
| PrEP optimism (n = 177)f | |||||
| Mean | 5.7 | 5.9 | 6 | 5.3 | 5.7 |
| Median (25th, 75th percentile) | 6.0 (5.0, 7.0) | 5.0 (5.0, 7.0) | 6.0 (5.0, 7.0) | 5.0 (5.0, 6.0) | 6.0 (5.0, 6.0) |
N (%) unless otherwise noted; column percentages calculated among those with non-missing covariate data.
Converted to $USD from ZAR.
Hopkins Symptom Checklist was used to derive depression scores.
Developed by Pulerwitz et al., the Sexual Relationship Power Score assesses Relationship Control and Decision-Making Dominance between a male and female partner.
Developed by Napper et al., the HIV-risk score assesses a person's perception of their risk of acquiring HIV based on their sexual and lifestyle habits.
Adapted from Kalichman SC., the PrEP optimism score assess a person's attitudes about taking PrEP for HIV prevention.