Table 5.
Pathways related to genetic variants for serum HDL concentration.
| Gene set | N of genes | Beta | Beta STD | SE | P value | P value with Bonferroni |
|---|---|---|---|---|---|---|
| GO BP: GO reverse cholesterol transport | 17 | 1.92 | 0.058 | 0.231 | 4.21e-17 | 6.52e-13 |
| GO BP: GO triglyceride-rich lipoprotein particle remodeling | 13 | 2.20 | 0.058 | 0.269 | 1.42e-16 | 2.20e-12 |
| GO BP: GO protein-containing complex remodeling | 30 | 1.37 | 0.055 | 0.117 | 4.49e-16 | 6.95e-12 |
| GO BP: GO cholesterol storage | 17 | 1.69 | 0.051 | 0.211 | 6.70e-16 | 1.04e-11 |
| GO BP: GO regulation of macrophage-derived foam cell differentiation | 30 | 1.26 | 0.050 | 0.163 | 8.00e-15 | 1.24e-10 |
| GO BP: GO very low-density lipoprotein particle remodeling | 11 | 2.14 | 0.052 | 0.289 | 6.40e-14 | 9.90e-10 |
| GO BP: GO positive regulation of cholesterol storage | 7 | 2.60 | 0.050 | 0.361 | 2.98e-13 | 4.61e-09 |
| GO BP: GO foam cell differentiation | 36 | 1.05 | 0.046 | 0.148 | 6.63e-13 | 1.03e-08 |
| GO BP: GO protein-lipid complex subunit organization | 50 | 0.90 | 0.046 | 0.127 | 6.97e-13 | 1.08e-08 |
| GO BP: GO high-density lipoprotein particle remodeling | 17 | 1.518 | 0.046 | 0.226 | 9.22e-12 | 1.423e-07 |
| GO BP: GO phospholipid homeostasis | 10 | 1.938 | 0.045 | 0.296 | 2.90e-11 | 4.493e-07 |
GO, Gene Ontology; BP, biological process.