TABLE 1.
Association between HLA haplotypes and regorafenib‐induced grade 3 EM.
| HLA haplotype | EM | OR (95% CI) | p | Corrected‐p | |
|---|---|---|---|---|---|
| Yes (N = 7) | No (N = 33) | ||||
| HLA‐A | |||||
| A*24:02 | 1 (14.3) a | 12 (36.4) | 0.292 (0.03–2.72) | 0.393 | 1.00 |
| A*02:01 | 1 (14.3) | 9 (27.3) | 0.444 (0.05–4.22) | 0.656 | 1.00 |
| A*02:06 | 1 (14.3) | 6 (18.2) | 0.750 (0.08–7.44) | 1.00 | 1.00 |
| A*11:01 | 2 (28.6) | 4 (12.1) | 2.90 (0.41–20.28) | 0.279 | 1.00 |
| A*31:01 | 1 (14.3) | 5 (15.2) | 0.933 (0.09–9.51) | 1.00 | 1.00 |
| A*33:03 | 1 (14.3) | 4 (12.1) | 1.21 (0.11–12.81) | 1.00 | 1.00 |
| A*02:07 | 2 (28.6) | 3 (9.09) | 4.00 (0.53–30.28) | 0.204 | 1.00 |
| A*26:03 | 1 (14.3) | 4 (12.1) | 1.21 (0.11–12.81) | 1.00 | 1.00 |
| A*11:02 | 1 (14.3) | 1 (3.03) | 5.33 (0.29–97.49) | 0.323 | 1.00 |
| A*02:03 | 1 (14.3) | 1 (3.03) | 5.33 (0.29–97.49) | 0.323 | 1.00 |
| A*26:05 | 1 (14.3) | 0 (0.00) | 15.5 (0.57–423.02) | 0.175 | 1.00 |
| A*24:07 | 1 (14.3) | 0 (0.00) | 15.5 (0.57–423.02) | 0.175 | 1.00 |
| HLA‐B | |||||
| B*51:01 | 2 (28.6) | 6 (18.2) | 1.80 (0.28–11.60) | 0.611 | 1.00 |
| B*15:01 | 1 (14.3) | 5 (15.2) | 0.933 (0.09–9.51) | 1.00 | 1.00 |
| B*54:01 | 3 (42.9) | 4 (12.1) | 5.44 (0.88–33.76) | 0.0877 | 1.00 |
| B*44:03 | 1 (14.3) | 5 (15.2) | 0.933 (0.09–9.51) | 1.00 | 1.00 |
| B*46:01 | 3 (42.9) | 2 (6.06) | 11.6 (1.47–92.14) | 0.0299 | 0.807 |
| B*48:01 | 1 (14.3) | 4 (12.1) | 1.21 (0.11–12.81) | 1.00 | 1.00 |
| B*59:01 | 1 (14.3) | 0 (0.00) | 15.5 (0.57–423.02) | 0.175 | 1.00 |
| B*15:18 | 1 (14.3) | 2 (6.06) | 2.58 (0.2–33.24) | 0.448 | 1.00 |
| B*08:01 | 1 (14.3) | 0 (0.00) | 15.5 (0.57–423.02) | 0.175 | 1.00 |
| HLA‐C | |||||
| C*01:02 | 6 (85.7) | 8 (24.2) | 18.8 (1.95–180.01) | 0.00437 | 0.118 |
| C*07:02 | 1 (14.3) | 8 (24.2) | 0.933 (0.09–9.51) | 1.00 | 1.00 |
| C*08:01 | 2 (28.6) | 6 (18.2) | 1.80 (0.28–11.60) | 0.611 | 1.00 |
| C*14:02 | 3 (42.9) | 7 (21.2) | 2.79 (0.5–15.46) | 0.338 | 1.00 |
| C*14:03 | 1 (14.3) | 5 (15.2) | 0.933 (0.09–9.51) | 1.00 | 1.00 |
| C*04:01 | 1 (14.3) | 1 (3.03) | 5.33 (0.29–97.49) | 0.323 | 1.00 |
Note: HLA haplotypes observed in patients who suffer grade 3 EM are listed.
Abbreviations: CI, confidence interval; EM, erythema multiforme; OR, odds ratio.
a
Number of patients (%).