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. 2023 Aug 10;16(10):1957–1971. doi: 10.1111/cts.13604

FIGURE 4.

FIGURE 4

TXNDC12 interacts with SLC7A11 in glioma cells. (a) U87 and U251 cells were transfected with control shRNA or TXNDC12 shRNA, and the expression of the indicated proteins was detected by Western blotting. (b) U87 and U251 cells were transfected with an empty vector and TXNDC12 OE, and the expression of the indicated proteins was detected by Western blotting. (c) U87 and U251 cells were treated with DMSO or erastin (10 μM or 20 μM) for 10 h, and the expression of the indicated proteins was detected by Western blotting. (d) U87 and U251 cells were transfected with TXNDC12 OE or SLC7A11 shRNA, and the expression of indicated proteins was detected by Western blotting. (e) U87 and U251 cells transfected with an empty vector and TXNDC12 OE and treated with DMSO or erastin (10 μM), and the expression of the indicated proteins was detected by Western blotting. (f) U87 and U251 cells transfected with control shRNA and TXNDC12 shRNA and treated with DMSO or erastin (10 μM), and the expression of the indicated proteins was detected by Western blotting. Data shown represent mean ± SD from three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. DMSO, dimethylsulfoxide; ns, not significant.