TABLE 4.
Mean intragastric pH >3, >4, and >5 HTRs (%) during the 24 h and during the night‐time period (12–24 h postdose) following multiple oral doses of keverprazan 20/40 mg, vonoprazan 20 mg, or placebo on day 1 and day 7 in healthy Chinese subjects.
| Parameters | Day 1 | Day 7 | ||||||
|---|---|---|---|---|---|---|---|---|
| Placebo (n = 6) | Vonoprazan 20 mg (n = 4) | Keverprazan 20 mg (n = 8) | Keverprazan 40 mg (n = 8) | Placebo (n = 6) | Vonoprazan 20 mg (n = 4) | Keverprazan 20 mg (n = 8) | Keverprazan 40 mg (n = 8) | |
| 24 h pH >3 HTR % | 9.4 ± 2.7 | 85.6 ± 9.2 | 85.5 ± 3.0 | 87.6 ± 12.5 | 7.6 ± 6.2 | 99.6 ± 0.7 | 99.6 ± 1.1 | 100.0 ± 0.0 |
| 24 h pH >4 HTR % | 5.6 ± 2.4 | 82.2 ± 12.6 | 85.0 ± 3.0 | 85.8 ± 16.9 | 4.5 ± 4.3 | 99.4 ± 1.2 | 98.3 ± 4.3 | 100.0 ± 0.0 |
| 24 h pH >5 HTR % | 3.1 ± 2.3 | 79.1 ± 15.4 | 84.4 ± 2.8 | 84.5 ± 19.8 | 3.2 ± 3.6 | 99.0 ± 1.8 | 97.4 ± 6.0 | 100.0 ± 0.0 |
| Night‐time pH >3 HTR % | 6.0 ± 5.6 | 93.7 ± 7.4 | 99.9 ± 0.0 | 97.8 ± 6.2 | 2.7 ± 4.3 | 99.2 ± 1.4 | 99.2 ± 1.9 | 99.9 ± 0.0 |
| Night‐time pH >4 HTR % | 3.9 ± 4.7 | 87.9 ± 15.7 | 99.9 ± 0.0 | 95.2 ± 13.5 | 1.5 ± 2.7 | 98.8 ± 2.3 | 96.9 ± 8.1 | 99.9 ± 0.0 |
| Night‐time pH >5 HTR % | 2.2 ± 3.7 | 82.4 ± 22.4 | 99.7 ± 0.6 | 93.6 ± 17.9 | 0.9 ± 1.9 | 98.1 ± 3.7 | 95.3 ± 11.4 | 99.9 ± 0.0 |
Abbreviation: HTRs, holding time ratios.