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. 2023 Aug 16;16(10):1982–1996. doi: 10.1111/cts.13606

FIGURE 2.

FIGURE 2

Box plots of distribution of exposure parameters by dose after single (a) and (b) multiple oral administrations of SN1011 to healthy subjects. Box plots of distribution of dose‐normalized exposure parameters by dose after single (c) and (d) multiple oral administrations of SN1011 to healthy subjects. Left: C max; mid: AUC0‐24; right: AUC0‐inf. Each plot in (a) and (c) shows the 100 mg (SAD), 200 mg (SAD and MAD day 1), 400 mg (SAD and MAD day 1), 600 mg (SAD, MAD day 1, and the fasted group in the food effect study), and 800 mg (SAD) dose groups from left to right. Each plot in (b) and (d) shows the 200, 400, and 600 mg dose groups at MAD day 10 from left to right. The horizontal line in the middle of the box plot represents the median, the boxes represent the four‐digit interval (1st quartile to 3rd quartile, or the interquartile range [IQR]), the whiskers represent 1.5*IQR, and the scatter outside the box plot represents discrete data; values below the box plot are the number of subjects included in the analysis. AUC0‐inf could not be accurately calculated and was not included in the analysis. C max, maximum blood concentration; AUC0‐24, area under the plasma concentration‐time curves from 0 to 24 h; AUC0‐inf, area under the plasma concentration‐time curve from time zero to time infinity; C max/dose, dose‐normalized maximum blood concentration; AUC0‐24/dose, dose‐normalized area under the plasma concentration‐time curve from 0 to 24 h; AUC0‐inf/dose, dose‐normalized area under the plasma concentration‐time curve from time zero to time infinity; MAD, multiple ascending doses; SAD, single ascending dose.