Table 1.
Abbreviations of sterol/SGA-biosynthetic enzymes, used in the present investigation.
| Abbreviation | Also denoted | Enzymatic function |
|---|---|---|
| HMGS | 3-Hydroxy-3-methylglutaryl-coenzyme A synthase | |
| HMGR | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase | |
| MVK | Mevalonate kinase | |
| PMVK | Phosphomevalonate kinase | |
| MVDPD | Mevalonate diphosphate decarboxylase | |
| IDI | IPPI | Isopentenyl diphosphate isomerase (IPP isomerase) |
| FPS | Farnesyl pyrophosphate synthase | |
| SQS | Squalene synthase | |
| SQE | Squalene epoxidase (monooxygenase) | |
| CAS/LAS | Cycloartenol/lanosterol synthase | |
| DWF1 | SSR1 | Sterol side-chain Δ24-reductase |
| DWF1-L | SSR2 | Sterol side-chain Δ24-reductase-like |
| SMO1 | Sterol methyl-oxidase 1-2 | |
| SMO1-L | Sterol methyl-oxidase 1-like | |
| SMO2 | Sterol C4 methyl oxidase 2 | |
| SMO2-L | Sterol C4 methyl oxidase 2-like | |
| SMT1 | Sterol C24-methyltransferase 1 | |
| SMT2 | Sterol C24-methyltransferase 2 | |
| DWF5 | Δ7 Sterol reductase | |
| DWF5-L | Δ7 Sterol reductase-like | |
| DWF7 | C5-SD1 | Δ7-C5 sterol desaturase |
| DWF7-L | C5-SD2 | Δ7-C5 sterol desaturase-like |
| CPI | Cyclopropyl isomerase | |
| SI | HYDRA | Δ8-Δ7 Sterol isomerase |
| FK | FACKEL | Δ14- Sterol reductase |
| CYP51 | Obtusifoliol C14-demethylase | |
| C22-desat. | CYP710A | Stigmasterol synthase |
| 3β-HSD | 3β-Hydroxysteroid-dehydrogenase/decarboxylase | |
| CYP72A188 | GAME6; PGA2 | Steroid C22-oxygenase |
| CYP72A208a | GAME8a | Cytochrome P450 |
| CYP72A208b | GAME8b; PGA1 | Steroid C26-oxygenase |
| CYP72A186 | GAME7 | Cytochrome P450 |
| CYP88B1 | GAME4 | Cholesterol C26-oxidase |
| 2-ODD (GAME11) | GAME11; 16DOX | 2-Oxoglutarate-dependent dioxygenase (GAME11) |
| 2-ODD (DPS) | DPS | 2-Oxoglutarate-dependent dioxygenase (DPS) |
| 2-ODD (GAME31) | GAME31 | 2-Oxoglutarate-dependent dioxygenase (GAME31) |
| TAM iso1 | GABA transaminase isoform 1 | |
| TAM iso2 | GAME12; PGA4 | GABA transaminase isoform 2 (TAM2) |
| TAM iso3 | GABA transaminase isoform 3 | |
| SGT1 | UDP-galactose:solanidine galactosyltransferase | |
| SGT2 | UDP-glucose:solanidine glucosyltransferase | |
| SGT3 | β-Solanine/β-chaconine rhamnosyltransferase | |
| GAME9 | JRE4 | Apetala/Ethylene response transcription factor |
An “-L” denotes proteins with a special role in cholesterol synthesis and being regulated by wound/light. A full list with corresponding potato genes is given in Table S1 .