Table 2 GLUT5-associated intestinal diseases and the role of GLUT5 in these diseases

Disease	Role of GLUT5	Reference
Gut microbiota dysbiosis/gut barrier dysfunction	Changes in dietary fructose levels and intestinal GLUT5 expression contribute to disease development by altering normal gut microbiota and gut barrier function.	[ 97– 105]
IBDs (including UC and CD)	GLUT5 promotes the formation and growth of blood vessels and lymphatic vessels in the lamina propria of the large intestine in patients with IBDs.	[ 106– 111]
CRC	High expression of GLUT5 promotes CRC cells proliferation, metastasis, invasion and enhances drug resistance of cancer cells.	[ 112– 121]
FM	Fructose malabsorption due to lack of ChREBP or rab11a, or low expression of GLUT5 itself.	[ 61, 122– 130]