Table 3 Malignant tumors associated with high GLUT5 expression mentioned in this review

Cancer	Expression of GLUT5	Influence	Reference
Colorectal cancer	Up-regulated	GLUT5 promotes cancer cell proliferation, migration and invasion, and enhances cancer cell drug resistance.	[ 114– 121]
Glioma	Up-regulated	GLUT5 is associated with tumor malignancy and poor patient survival.	[132]
Ovarian cancer	Up-regulated	GLUT5 is associated with tumor malignancy and poor patient survival.	[133]
Lung adenocarcinoma	Up-regulated	GLUT5 promotes cancer cell proliferation, migration, invasion and tumorigenicity, enhances cancer cell drug resistance and is associated with poor patient prognosis.	[ 134, 135]
Breast cancer	Up-regulated	GLUT5 promotes tumor progression.	[137]
Acute myeloid leukemia	Up-regulated	GLUT5 promotes tumor progression.	[138]
Clear cell renal cell carcinoma	Up-regulated	GLUT5 promotes tumor progression.	[139]
Cholangiocarcinoma	Up-regulated	Cancer cells with high GLUT5 expression showed increased cell proliferation and ATP synthesis.	[143]
Oral squamous cell carcinoma	Up-regulated	Up-regulated GLUT5 mediates increased uptake and utilization of fructose by cancer cells induced by IL-6.	[144]
Prostate cancer	Up-regulated	Up-regulated GLUT5 mediates increased uptake and utilization of fructose by cancer cells induced by IL-6.	[ 136, 144]
Pancreatic cancer	Up-regulated	GLUT5-mediated fructose uptake and utilization promote nucleotide synthesis in cancer cells.	[147]