Table 5.
The causal association between sarcopenia and risk of any death.
| Exposure | Outcome | nSNP | OR | 95% CI | p | Heterogeneity test | Pleiotropy_test | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Cochran’s Q | p | Intercept | p | |||||||
| Appendicular lean mass | Any death | 283 | MR-Egger | 1.261 | 1.056–1.507 | 0.011 | 245.388 | 0.980 | −0.008 | 0.001 |
| 283 | Weighted median | 0.948 | 0.850–1.058 | 0.341 | ||||||
| 283 | IVW | 0.954 | 0.892–1.021 | 0.176 | ||||||
| Low hand grip strength (60 years and older) (EWGSOP) | Any death | 11 | MR-Egger | 1.077 | 0.523–2.218 | 0.846 | 14.605 | 0.147 | 0.012 | 0.590 |
| 11 | Weighted median | 1.168 | 0.902–1.512 | 0.238 | ||||||
| 11 | IVW | 1.310 | 1.058–1.621 | 0.013 | ||||||
| Usual walking pace | Any death | 52 | MR-Egger | 0.404 | 0.057–2.874 | 0.369 | 38.768 | 0.896 | 0.003 | 0.697 |
| 52 | Weighted median | 0.587 | 0.294–1.173 | 0.131 | ||||||
| 52 | IVW | 0.590 | 0.367–0.950 | 0.030 | ||||||
SNP, single-nucleotide polymorphism; MR, Mendelian randomization; IVW, inverse variance weighted; EWGSOP, European Working Group on Sarcopenia in Older People.