TABLE 1.
Study subject characteristics
| Characteristica | Value for:
|
|
|---|---|---|
| Normal subjects | Thalassemic subjects | |
| No. studied | 10 | 10b |
| Male subjects (%) | 40 | 20 |
| Age (yr)c | 21.8 ± 1.7 (20–25) | 23.6 ± 3.3 (18–28) |
| Wt (kg)c | 50 ± 6.4 (43–52) | 53.4 ± 6.2 (45–57) |
| Hematologyc | ||
| Erythrocyte count (1012/liter) | 5.06 ± 0.45 (4.55–5.68) | 4 ± 0.4 (3.57–4.62) |
| Hemoglobin (g/dl) | 14.78 ± 1.02 (13.5–16) | 8 ± 0.3 (7.6–8.3) |
| Hematocrit (%) | 43.9 ± 5.02 (39.9–47.4) | 27 ± 0.9 (26.2–28.6) |
| CV (fl) | 86.86 ± 2.98 (81.6–88.7) | 68 ± 5.2 (62–73.3) |
| CH (pg) | 29.26 ± 0.69 (28.2–29.8) | 20 ± 1.6 (17.7–21.8) |
| CHC (g/dl) | 33.64 ± 0.54 (32.9–34.4) | 30 ± 1.3 (28.3–31.1) |
| Blood chemistryc | ||
| BUN (mg/dl) | 10.6 ± 2.61 (8–16) | 8.6 ± 2.3 (7–12) |
| Creatinine (mg/dl) | 1.02 ± 0.13 (0.9–1.2) | 0.72 ± 0.13 (0.6–0.9) |
| Total protein (g/dl) | 8.3 ± 0.46 (7.8–9) | 7.66 ± 0.54 (7–8.5) |
| Albumin (g/dl) | 4.9 ± 0.34 (4.5–5.1) | 4.66 ± 0.35 (4.3–5.1) |
| Globulin (g/dl) | 2.7 ± 0.44 (2.4–3.2) | 3.3 ± 0.5 (2.2–3.4) |
| Total bilirubin (mg/dl) | 0.9 ± 0.23 (0.7–1.2) | 1.82 ± 1.08 (1–3.2) |
| Direct bilirubin (mg/dl) | 0.28 ± 0.11 (0.1–0.4) | 0.32 ± 0.04 (0.3–0.4) |
| AST (U/liter) | 19.8 ± 2.49 (18–23) | 37.6 ± 3.9 (31–40) |
| ALT (U/liter) | 16.6 ± 9.04 (8–26) | 16.8 ± 2.95 (13–21) |
a
CV, corpuscular volume; CH, corpuscular hemoglobin; CHC, corpuscular hemoglobin concentration; BUN, blood urea nitrogen; AST, aspartate aminotransferase; ALT, alanine aminotransferase.
b
Two subjects had α-thal1–Hb CS, and eight subjects had α-thal1–α-thal2.
c
Data shown are means ± standard errors at 95% confidence intervals (ranges are in parentheses).