TABLE 2.
Pharmacokinetic data following a single intravenous injection of artesunate (2.4 mg/kg of body weight) into 10 normal individuals and 10 thalassemic individuals
| Subjects | Valuea for:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Cmax (nmol/liter)b | Clast (nmol/liter)b | t1/2 (h)c | AUC (nmol/liter/h)b | λ (h)d | RT (min)e | CL (liter/h)f | Vss (liter/kg)f | |
| Normal | 306 ± 259 (94–913) | 2.5 ± 2.9 (0.5–9.6) | 1.37 ± 0.59 (1.04–2.06) | 147 ± 46.5 (95.2–215) | 0.43 ± 0.19 (0.34–0.67) | 33 ± 13 (17–57) | 38 ± 4.3 (25.3–56.5) | 48 ± 11 (12.4–95.9) |
| Thalassemic | 4,761 ± 2,561 (1,006–8,787) | 14.6 ± 6.46 (3.88–26.3) | 1.95 ± 0.82 (1.08–3.51) | 1,316 ± 613 (420–2,445) | 0.40 ± 0.14 (0.2–0.64) | 59 ± 21 (21–87) | 4.1 ± 0.54 (3–9) | 3.2 ± 0.78 (1.6–7.3) |
a
Data shown are means ± standard errors at 95% confidence intervals (ranges are in parentheses). Cmax, peak concentration in plasma; Clast, last concentration in plasma; AUC, area under the concentration-time curve; λ, terminal elimination rate constant; RT, residence time; CL, clearance.
b
P < 0.001.
c
P = 0.174.
d
P = 0.545.
e
P = 0.01.
f
P = 0.001.