TABLE 4.

Synergy^c of azoles and DETA-NO against Candida strains

Azole	Strain	MIC (μg/ml) of:		FICa	MIC (μg/ml) of:		FIC	FIXb
		Azole alone	Azole with DETA-NO		DETA-NO alone	DETA-NO with azole
Ketoconazole	C. albicans	2.00	0.004	0.002	2,000	400	0.200	0.202
	C. krusei	8.00	0.100	0.013	1,200	400	0.333	0.346
	C. parapsilosis	0.08	0.003	0.038	800	300	0.375	0.413
	C. tropicalis	4.00	0.200	0.050	2,200	300	0.136	0.186
	C. glabrata	15.00	0.500	0.033	1,600	400	0.250	0.283
	C. dubliniensis	4.00	0.250	0.063	2,000	300	0.150	0.213
Fluconazole	C. albicans	16	0.24	0.015	2,000	500	0.250	0.265
	C. krusei	120	15.00	0.125	1,200	400	0.333	0.458
	C. parapsilosis	2	0.25	0.125	800	200	0.250	0.375
	C. tropicalis	160	5.00	0.031	2,200	200	0.091	0.122
	C. glabrata	180	5.00	0.028	1,600	300	0.188	0.216
	C. dubliniensis	60	2.50	0.042	2,000	300	0.150	0.192
Miconazole	C. albicans	2	0.020	0.010	2,000	400	0.200	0.210
	C. krusei	15	1.400	0.093	1,200	400	0.333	0.426
	C. parapsilosis	6	0.100	0.017	800	300	0.375	0.392
	C. tropicalis	4	0.400	0.100	2,200	400	0.182	0.282
	C. glabrata	6	0.090	0.015	1,600	500	0.313	0.328
	C. dubliniensis	4	0.045	0.011	2,000	400	0.200	0.211

^aFIC, fractional inhibitory concentration (MIC of drug in combination/MIC of drug alone). 

^bFIX, fractional inhibitory concentration index (MIC of DETA-NO in combination with azole/MIC of DETA-NO alone) + (MIC of azole in combination with DETA-NO/MIC of azole alone). 

^cAll outcomes were synergistic (FIX, ≤0.5).