Table 5.

NLR, SII, and LDH according to line of ICIs by univariate analysis

	First line (n = 582)	2+ treatment line (n = 587)
	HR (95% CI); p value	HR (95% CI); p value
NLR (continuous; 10-unit difference)	1.43 (1.22–1.66); p < 0.001, c-index = 0.622	1.13 (1.02–1.25); p = 0.016, c-index = 0.576
NLR
<4.0	1.00 (ref)	1.00 (ref)
≥4.0	2.14 (1.63–2.81); p < 0.001, c-index = 0.589	1.39 (1.10–1.75); p = 0.006, c-index = 0.551
NLR
<3.4	1.00 (ref)	1.00 (ref)
≥3.4	2.11 (1.60–2.78); p < 0.001, c-index = 0.594	1.38 (1.10–1.74); p = 0.006, c-index = 0.551
SII (continuous; 1,000-unit difference)	1.09 (1.05–1.13); p < 0.001, c-index = 0.619	1.04 (1.01–1.07); p = 0.008, c-index = 0.576
SII
<831	1.00 (ref)	1.00 (ref)
≥831	2.01 (1.52–2.67); p < 0.001, c-index = 0.586	1.53 (1.21–1.93); p < 0.001, c-index = 0.560
SII
<1,444	1.00 (ref)	1.00 (ref)
≥1,444	1.94 (1.46–2.57); p < 0.001, c-index = 0.573	1.48 (1.16–1.90); p = 0.002, c-index = 0.545
dNLR
≤3	1.00 (ref)	1.00 (ref)
>3	2.33 (1.72–3.17); p < 0.001, c-index = 0.573	1.39 (1.01–1.92); p = 0.042, c-index = 0.528
LDH
<ULN	1.00 (ref)	1.00 (ref)
≥ULN	1.34 (0.98–1.84); p = 0.065, c-index = 0.529	1.39 (1.04–1.86); p = 0.027, c-index = 0.529

95% CI, 95% confidence interval; dNLR, derived neutrophil-to-lymphocyte ratio; HR, hazard ratio; LDH, lactate dehydrogenase; n, number; NLR, neutrophil-to-lymphocyte ratio; RCC, renal cell carcinoma; SII, systemic immune-inflammatory index.