Table 1.
Included randomised controlled trials (RCTs) with sample sizes
| Drug | RCTs (N) | RCTs with low/moderate/high risk of bias (N) | Total (N) | Drug (N) | Placebo (N) |
| N-acetyl-cysteine | 8 | 3/4/1 | 523 | 258 | 265 |
| Sarcosine | 6 | 0/4/2 | 211 | 104 | 107 |
| Minocycline | 8 | 4/3/1 | 583 | 298 | 285 |
| PUFA | 14 | 5/5/4 | 809 | 432 | 377 |
| Oestrogens | 9 | 5/3/1 | 677 | 383 | 294 |
| Selective estrogen receptor modulator (raloxifene) | 9 | 6/3/0 | 552 | 275 | 277 |
| Aspirin | 4 | 0/3/1 | 424 | 221 | 203 |
| Celecoxib | 5 | 1/3/1 | 440 | 222 | 218 |
| Total | 63 | 24/28/11 | 4219 | 2193 | 2026 |
PUFA, polyunsaturated fatty acid; SERM, selective estrogen receptor modulator.