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. 2023 Sep 12;299(10):105246. doi: 10.1016/j.jbc.2023.105246

Figure 4.

Figure 4

Examples of translation dynamic control through tRNA pool modulation.A, dysregulation in tRNA pools or (B) synonymous SNPs encoding rare codons alter translation kinetics and cotranslational folding, leading to changes in protein expression and increased protein misfolding, aggregation, and proteolysis. C, codon usage impacts steady-state protein output by regulation of translation efficiency and mRNA stability. By restoring tRNA pool imbalance with a tRNA medicine, a baseline steady state can be restored.