Fig. 1.

Effect of antibiotics on bacterial diversity in the vagina versus gut.

A, Design of the experiment. B, Imaging of intravaginal TC-1 tumors following injection, IVIS imaging was performed on days 1, 5, 8, 12 and 15 following intraperitoneal injection of coelentrazine, red circle demonstrates the region of interest for measuring photons/second using bioluminescent imaging to quantitate tumor burden, T2 weighted MRI was performed on day 15 with red arrow pointing to tumor mass. C, Opposite changes in diversity of bacterial communities after AB treatment in gut and in vagina. D, Changes in distribution of species with different abundances in the gut and in the vagina after AB treatment, RLR is the ratio of low abundant species (log10 of the abundance < 0.2) to the rest.