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. 2023 Oct 18;13(10):e1460. doi: 10.1002/ctm2.1460

FIGURE 1.

FIGURE 1

Regulation of the m6A modification. The m6A RNA modification is reversibly regulated by m6A methyltransferases (writers), m6A demethylases (erasers) and m6A‐binding proteins (readers). The writers are responsible for adding methyl groups to the N6 position of adenosine of specific RNAs, whereas erasers remove the methyl groups. The readers, on the other hand, are RBPs that can recognise and interpret the m6A modification, thereby affecting various diverse of RNA metabolism such as mRNA translation, decay, stability, splicing and localisation.