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The mechanism of YTHDC1 in regulating alternative splicing. YTHDC1 selectively recruits SRSF3 over SRSF10 to facilitate the inclusion of specific exons in m6A‐modified mRNAs. However, this preference is disrupted when the m6A modification disappears. In addition, AURKA, which is transported into the nucleus recruits hnRNPK to YTHDC1, leading to exon skipping event.
