Table 3.

Mediation models of the association among TNF-a, LTL, and kidney outcome.

	Rapid decline in renal function		Composite endpoint(n=59)
	Estimate (95%CI)	p value	Estimate (95%CI)	p value
All participants
Total effect	0.059 (0.019,0.110)	<0.001	0.058 (0.008,0.110)	<0.001
Indirect effect	0.013 (0.003,0.020)	0.040	0.009 (-0.003,0.020)	0.200
Direct effect	0.046 (0.006,0.090)	<0.001	0.048 (-0.004,0.100)	0.080
Prop. Mediated	0.224 (0.040,0.680)	0.040	0.181 (-0.045,1.570)	0.200
Participants with hypertension
Total effect	-0.002 (-0.164,0.200)	0.960	0.147 (0.047,0.230)	<0.001
Indirect effect	-0.001 (-0.080,0.050)	0.800	0.005 (-0.023,0.030)	0.640
Direct effect	-0.001 (-0.116,0.160)	0.920	0.141 (0.050,0.230)	<0.001
Prop. Mediated	0.206 (0.000,0.540)	0.040	0.030 (-0.135,0.330)	0.640

Models were adjusted for age, sex,BMI,HbA1c,SBP,DBP,LDL-C,TG,UA,baseline ACR and baseline eGFR. Bold font indicates statistical differences.