FIGURE 2.

Visual predictive check of observed data against (a) individual and population predictions from the longitudinal M‐protein model and (b) median predicted cumulative transition probability versus pharmacokinetic effect concentration in the final ocular adverse events discrete time Markov model.

(a) Individual time courses shown with trendline; (b) observed data shown as bars, predictions by the model as lines. Pharmacokinetic effect concentrations were binned into 10 quantiles of equal size, with the median probability taken over all samples in the bin with the same observed previous state. The cross and error bars indicate 95% confidence intervals of the observed and predicted values, respectively. The median values do not necessarily sum to 1.