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. 2023 Sep 15;12(10):1485–1498. doi: 10.1002/psp4.13025

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© 2023 Janssen. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic of the mechanistic model for humoral immune response following a single dose regimen or a homologous booster regimen of Ad26.COV2.S in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)‐seronegative participants. Modified from “Quantifying Antibody Persistence After a Single Dose of COVID‐19 Vaccine Ad26.COV2.S in Humans Using a Mechanistic Modeling and Simulation Approach” by A. Dari et al., 2023, Clinical Pharmacology & Therapeutics, Feb;113(2):380–389. IC₅₀, 50% maximal inhibitory concentration; S‐ELISA, spike protein enzyme‐linked immunosorbent assay; wtVNA, wild‐type virus neutralizing assay.