Table 2.
Polymer NPs for the delivery of siRNA
| Polymeric NPs | Study | Cell lines | Aid | Ref. |
|---|---|---|---|---|
| PEI-HYD | In vivo and in vitro | HUVECs | Targeted delivery | [151] |
| PLGA | In vitro | H1299 | Improved encapsulation efficiency, high stability, highly resistant to nuclease degradation | [152] |
| PLGA-PLL-PEG | In vitro | HEK293T and A549 | Site-specific delivery, improved endosomal escape and controlled release | [153] |
| Chitosan | In vivo and in vitro | H1299; NIH 3T3; mouse lung | Enhanced transfection efficiency, protection from nuclease degradation, low cytotoxicity | [154] |
| Chitosan-mPEG | In vivo | Mouse xenograft | Improved cell permeability and blood retention time | [155] |