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. 2023 Oct 17;21:378. doi: 10.1186/s12951-023-02078-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vitro cytotoxicity of B7H3/DOX@GNCs in NCI-H1299 cells. A, B Cytotoxicity of B7H3/DOX@GNCs under with diffrent NIR irradiation time on NCI-H1299 cells for 24 h. C Cytotoxicity of different concentrations of GNCs, Dox, DOX@GNCs, B7H3@GNCs, and B7H3/DOX@GNCs with/without irradiation on NCI-H1299 cells for 24 h and cell viability was assessed by MTT assay. D Live/dead cell staining assay results of NCI-H1299 cells treated with GNCs, B7H3@GNCs, DOX@GNCs, and B7H3/DOX@GNCs with or without NIR radiation. Live cells were stained with calcein (green), and dead cells were stained with propidium iodide (red). Data are Mean ± SD (n = 3), ^*P < 0.05 and ^**P < 0.01, (one-sample t-test) versus GNCs group