Skip to main content
. 2023 Oct 17;21:378. doi: 10.1186/s12951-023-02078-9

Table 1.

Pharmacokinetic parameters of Dox•HCl, Dox@GNCs, and B7H3/Dox@GNCs after single intravenous administration in rats (Mean ± SD, n = 6)

PK Parameters Dox•HCl Dox@GNCs B7H3/Dox@GNCs
T1/2 (h) 8.67 ± 0.34 14.72 ± 1.36** 21.32 ± 2.46**
AUC0-∞ (h·mg/mL) 36.49 ± 1.27 245.48 ± 17.92** 568.45 ± 36.54**
Vd (L/kg) 1.64 ± 0.41 1.15 ± 0.63** 0.87 ± 0.56**
CL (L/h/kg) 0.13 ± 0.00 0.08 ± 0.00** 0.05 ± 0.00**
MRT0-∞(h) 9.43 ± 0.46 15.97 ± 1.54** 23.48 ± 2.06**

*P < 0.05, **P < 0.01 versus Dox•HCl group (one-sample t-test)