TABLE 2.

PAEs and PA-SMEs of L-749,345^a

Strain	PAE (h)	PA-SME (h) of L-749,345 at the following multiples of the MIC:
		0.1×	0.2×	0.3×	0.4×	0.5×
S. aureus ATCC 29231	1.5 (1.4–1.6)	2.0 (1.9–2.1)	2.4 (2.3–2.6)	2.9 (2.9–3.0)	3.6 (3.4–4.1)	4.2 (4.1–4.3)
S. pneumoniae ATCC 6306	2.4 (2.1–2.6)	3.5 (3.0–3.9)	4.3 (4.1–4.6)	6.9 (5.4–9.0)	>15.7 (>15.7)	>15.7 (>15.7)
H. influenzae NTCC 8468	0 (0)	1.8 (0.0–1.9)	3.7 (3.1–4.0)	6.9 (6.6–7.1)	10.1 (9.6–10.7)	11.7 (11.4–12.4)
E. coli ATCC 25922	−0.3 (−0.1–−0.4)	0.2 (0–0.3)	0.6 (0.4–0.9)	1.0 (0.9–1.3)	1.6 (1.4–2.0)	3.1 (2.3–3.6)
E. cloacae EN 20	0.3 (0–0.7)	1.6 (1.4–2.0)	3.3 (3.0–3.4)	5.0 (4.0–6.4)	6.5 (5.3–7.9)	7.6 (5.3–9.0)

^aValues are means (ranges).