TABLE 4.

PAEs and PA-SMEs of imipenem^a

Strain	PAE (h)	PA-SME (h) of imipenem at the following multiples of the MIC:
		0.1×	0.2×	0.3×	0.4×	0.5×
S. aureus ATCC 29231	1.3 (1.1–1.6)	2.1 (2.0–2.3)	3.2 (3.0–3.5)	5.1 (4.7–5.5)	8.3 (8.1–8.5)	>14.8 (>14.8)
S. pneumoniae ATCC 6306	2.4 (2.1–2.7)	3.1 (2.9–3.3)	3.8 (3.4–4.1)	5.2 (4.7–5.7)	6.4 (5.7–7.0)	7.6 (6.7–8.4)
H. influenzae NTCC 8468	−0.5 (−1.4–0)	6.4 (2.9–8.7)	9.9 (8.7–10.7)	>10.7 (>10.7)	>10.7 (>10.7)	>10.7 (>10.7)
E. coli ATCC 25922	−0.9 (−0.8–−1.0)	−0.2 (−1.0–−0.6)	7.9 (7.1–8.1)	13.9 (13.5–14.3)	>15 (>15)	>15 (>15)
E. cloacae EN 20	0.3 (0.2–0.4)	0.5 (0.5–0.5)	0.8 (0.7–0.8)	1.8 (1.6–2.0)	4.1 (3.8–4.4)	6.2 (5.5–6.8)

^aValues are means (ranges).