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. 2023 Oct 17;21:732. doi: 10.1186/s12967-023-04581-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — HIF1A bound to LINC02913 promoter region to inhibit its expression. A The transfection efficiency of HIF1A overexpression plasmid (HIF1A) and siRNA (si-HIF1A) was detected using western blot; B LINC02913 expression was detected after HIF1A overexpression and knockdown using qRT-PCR; C the binding of HIF1A with LINC02913 promoter region was verified using ChIP assay; D the binding between HIF1A and LINC02913 promoter region was verified using the dual-luciferase reporter gene assay; **p < 0.01, compared with the vector group; ##p < 0.01, compared with the si-NC group