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. 2023 Oct 17;21:732. doi: 10.1186/s12967-023-04581-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The LINC02913/IGF1R axis affected the phenotype of ADSCs under hypoxia via regulating the PI3K/AKT pathway. A IGF1R mRNA expression in ADSCs cultured under different oxygen concentrations was detected using qRT-PCR; B IGF1R protein level in ADSCs cultured under different oxygen concentrations was detected using western blot; C the effect of the LINC02913/IGF1R axis on IGF1R expression under hypoxia was detected through a series of rescue experiments using western blot; D the effect of the LINC02913/IGF1R axis on the PI3K/AKT pathway-related protein was detected using western blot; E the effect of the LINC02913/IGF1R axis on cell viability under hypoxia was detected using CCK-8 assay; F cell adipogenic ability under hypoxia was detected using oil red O staining; G after the endothelial differentiation of ADSCs, the effect of the LINC02913/IGF1R axis on cell tube formation under hypoxia was detected; H the effect of the LINC02913/IGF1R axis on the expression of CD31 (endothelial cell marker) was detected using IF staining; I the effect of the LINC02913/IGF1R axis on the level of endothelial cell markers CD133, CD31, VEGFA, and eNOS were detected using western blot. *p < 0.05, **p < 0.01, compared with the vector group; ##p < 0.01, compared with the LINC02913 OE group