Fig. 7.

Effects of LINC02913/IGF1R axis on hypoxia-ADSCs treated skin wound healing. The skin wound healing nude mice model was established and divided into 4 groups (N = 6 per group): hypoxia-ADSCs+ vector group (model mice were treated with hypoxia-ADSCs which were transfected with empty vector); hypoxia-ADSCs+ LINC02913 OE group (model mice were treated with hypoxia-ADSCs which were transfected with LINC02913 overexpression vector); hypoxia-ADSCs+ IGF1R OE group (model mice were treated with hypoxia-ADSCs which were transfected with IGF1R overexpression vector); hypoxia-ADSCs+ LINC02913 OE+IGF1R OE group (model mice were treated with hypoxia-ADSCs which were transfected with LINC02913 and IGF1R overexpression vectors). A skin wounds on days 1, 5, and 10 after wound puncture were exhibited, and then the percentage of wound area was calculated. B H&E staining was used to detect the pathological damage in wounded skin. C IHC staining was applied to detect CD31 expression in wounded skin. **p < 0.01, compared with vector group; ##p < 0.01, compared with LINC02913 overexpression group