TABLE 2.

Tissue burden in mice infected with H. capsulatum and treated with nikkomycin Z, fluconazole, or both drugs

Expt	Inoculum (CFU)	Drugb	Dose (mg/kg)	Tissue burden (105 CFU/g) ina:
				Spleen			Liver			Brain
				Mean	Lower CI	Upper CI	Mean	Lower CI	Upper CI	Mean	Lower CI	Upper CI
5 (n = 7/group)	2.3 × 105	None		1.98	1.01	4.95	1.28	6.05	28.06	0.05	0.03	0.14
		Nik Z	2.5	0.22*	0.06	0.61	2.12*	1.14	5.27	0.06	0.03	0.05
			5	0.11*	0.06	0.27	1.89*	1.01	4.69
			10	0.12*	0.06	0.30	2.64*	1.42	6.57	0.02	0.01	0.05
			25	0.07*	0.04	0.19	0.71*	0.38	1.77	0.13	0.07	0.33
		Flu	5	3.72	1.99	9.22	8.46	4.53	21.03	0.07	0.04	0.18
6 (n = 7/group)	7 × 105	None		10.89	5.84	27.09	60.26	32.30	149.90	0.64	0.34	1.59
		Nik Z	5	1.96*	1.05	4.87	6.97*	3.74	17.34	0.38	0.20	0.94
			25	0.44*	0.24	1.10	10.16*	5.44	25.26	0.61	0.33	1.53
		Flu	5	4.08	2.19	10.15	19.43*	10.41	48.33	0.50	0.27	1.26
		Nik Z + Flu	5 + 5	0.50**	0.30	1.21	2.79*	1.50	6.95	0.33	0.18	0.82
			5 + 25	0.37*	0.20	0.92	2.87*	1.54	7.14

^aLower CI, lower 95% confidence interval; Upper CI, upper 95% confidence interval. *, significantly different from control (none) (P < 0.05); **, significantly different from control (P < 0.01). 

^bNik Z, nikkomycin Z; Flu, fluconazole.