TABLE 3.

Network properties at the level of ATC category in the static PK, PD, and complete DDI networks.

		PK DDI network				PD DDI network				Complete DDI network
ATC 1st level code	Anatomical or pharmacological groups	Node	Edge	E-I index	Sig. pair a (OR)	Node	Edge	E-I index	Sig. Pair (OR)	Node	Edge	E-I index	Sig. Pair (OR)
A	Alimentary tract and metabolism	1,515	2,456	0.799	N (5.54)	2,495	4,596	0.797	N (2.57)	3,118	6,354	0.801	N (1.63)
B	Blood and blood forming organs	655	922	0.902	V (6.17)	1,369	2,096	0.846	D (2.23)	1,661	2,788	0.857	D (1.41)
C	Cardiovascular system	1,537	2,362	0.699	B (5.1)	2,579	4,482	0.702	H (2.11)	3,147	6,185	0.708	N (1.22)
D	Dermatologicals	688	1,007	0.904	J (5.23)	1,498	2,328	0.832	J (3.51)	1,813	3,061	0.851	J (2.02)
G	Genito urinary system and sex hormones	453	571	0.897	H (6.57)	895	1,543	0.898	A (1.69)	1,033	1,923	0.9
H	Systemic hormonal preparations, excluding sex hormones and insulins	63	70	0.941	V (12.3)	118	152	0.96	B (2.1)	159	212	0.942
J	Antiinfective for systemic use	652	1,054	0.676	P (8.4)	763	1,071	0.808	D (3.51)	1,112	2,025	0.746	S (1.98)
L	Antineoplastic and immunomodulating agents	806	1,217	0.719	S (5.43)	1,673	3,175	0.393	P (2.66)	1,940	4,066	0.496	P (1.66)
M	Musculo-skeletal system	332	430	0.928	N (5.39)	721	1,117	0.89	N (2.33)	873	1,425	0.906	N (1.7)
N	Nervous system	1,665	2,209	0.66	A (5.54)	2,879	4,864	0.657	A (2.57)	3,450	6,401	0.664	M (1.7)
P	Antiparasitic products, insecticides, and repellents	58	68	0.875	J (8.4)	176	219	0.904	V (3.83)	205	263	0.896	V (2.58)
R	Respiratory system	421	583	0.929	N (4.38)	807	1,239	0.887	C (1.76)	987	1,698	0.896	A (1.18)
S	Sensory organs	875	1,463	0.895	L (5.43)	1,677	2,738	0.833	J (3.34)	1,966	3,812	0.86	P (1.99)
V	Various	133	146	0.972	H (12.3)	358	482	1	P (3.83)	434	586	0.993	P (2.57)
No ATC	No ATC	349	408	0.95		800	1,140	0.942		990	1,463	0.944

^aThe ATC-ATC, pair with the highest odds ratio and adjusted p-value <0.05.