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The drugs with the highest average, as well as growth rate, in the three types of centrality (degree, betweenness, and eigenvector) over the last 5 years.
| PK | PD | Complete | ||
| Largest increase | Degree | Rifampin | Cisplatin | Rifampin |
| Betweenness | Rifampin | Morphine | Rifampin | |
| Eigenvector | Ketoconazole | Fluoxetine | Fluoxetine | |
| Lowest increase (or largest decrease) | Degree | Chlordiazepoxide | Trimethaphan | Meprobamate |
| Betweenness | Hexobarbital | Oxygen | Rimantadine | |
| Eigenvector | Cimetidine | Reserpine | Reserpine |
