Table 5. Comparison of first-line and second-line therapies for RRMS.

RRMS: relapsing-remitting multiple sclerosis

Criteria	First-line therapies	Second-line therapies
Efficacy	Moderate to high	High
Compliance	Low to moderate	Moderate to high
Relapse rate	Moderate	Low
Adverse effects	Mild to moderate	High
Discontinuation rate	Moderate	High
Cost	Moderate to high	High