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NTZ inhibition of GI.1 HuNoV replication in jejunal HIEs parallels its cytotoxicity. J4FUT2 HIEs were treated with five ascending doses of NTZ and the vehicle (1% DMSO) for 24 h. (A) Replication of GI.1 with NTZ treatment. (B) Percent inhibition of GI.1 by NTZ. (C) Percent viability was assessed in the J4FUT2 HIE line after 24 h. Based on EC50 and CC50 (panels B and C, respectively), the SI was calculated as 2.7. **P ≤ 0.01, ****P ≤ 0.0001. Data are compiled from n = 2 experiments.
