TABLE 2.
Minimal inhibitory concentrations (mg/L) and EC50 of IMI at the start (EC50,off) of the first TKC and at the end (EC50,on) of the second TKC (mg/L) of PAO1 and mutant-derived strains
| MIC | EC50,off [CI 95%] b | EC50,on [CI 95%] | EC50,on/EC50,off | |
|---|---|---|---|---|
| (mg/L) | mg/L | mg/L | ||
| Mutant-derived reference strains | ||||
| PAO1 | 0.5 | 0.411 [0.250–0.638] |
24.8 [21.3–29.3] |
60.3 |
| PAO1- AmpCG183D | 0.125 | 1.86 [1.49–2.26] (4.5 a ) |
2.25 [1.91–2.57] |
1.2 |
| PAO1- AmpDH157Y | 0.5 | 2.03 [1.58–2.64] (4.9 a ) |
7.68 [4.62–11.1] |
3.8 |
| PAO1- AmpCG183D/AmpDH157Y | 0.125 | 0.495 [0.397–0.603] (1.2 a ) |
3.29 [2.84–3.80] |
6.6 |
a
fold-change compared to initial strain PAO1.
b
CI 95%, Confidence intervals 95%.