. 2023 Oct 18;131(10):107008. doi: 10.1289/EHP12634

Table 5.

Association between childhood acute leukemia and density of vines within $1,000 meters$ of the geocoded address, stratifying by region (GEOCAP, inclusions 2006–2013, exposure assessment based on RPG and CLC, and on RPG only).

	Controls	All acute leukemia							Acute lymphoblastic leukemia							Acute myeloid leukemia
	$n$	$n$	RPG and CLC			RPG only		—	$n$	RPG and CLC			RPG only			$n$	RPG and CLC			RPG only
	$n$	$n$	OR^a	(95% CI)	$p$ ^b	OR^a	(95% CI)	$p$ ^b	$n$	OR^a	(95% CI)	$p$ ^b	OR^a	(95% CI)	$p$ ^b	$n$	OR^a	(95% CI)	$p$ ^b	OR^a	(95% CI)	$p$ ^b
Region^c					$less than 0.01$			$less than 0.01$				$less than 0.01$			$less than 0.01$				0.12			0.17
Occitanie	3,223	297	1.04	(0.97, 1.12)	—	1.17	(0.98, 1.40)	—	251	1.06	(0.99, 1.15)	—	1.24	(1.03, 1.48)	—	38	0.90	(0.71, 1.16)	—	0.71	(0.32, 1.58)	—
Nouvelle-Aquitaine	3,251	319	0.97	(0.87, 1.07)	—	0.80	(0.59, 1.09)	—	268	0.99	(0.89, 1.10)	—	0.85	(0.63, 1.16)	—	49	0.83	(0.58, 1.19)	—	0.46	(0.12, 1.74)	—
PACA-Corse	3,078	293	1.10	(0.97, 1.24)	—	1.30	(0.90, 1.87)	—	241	1.09	(0.95, 1.25)	—	1.30	(0.86, 1.96)	—	48	1.14	(0.88, 1.47)	—	1.44	(0.70, 2.98)	—
Auvergne-Rhône-Alpes	4,942	455	0.75	(0.56, 0.99)	—	0.50	(0.24, 1.07)	—	373	0.56	(0.33, 0.94)	—	0.46	(0.19, 1.12)	—	70	1.07	(0.80, 1.44)	—	0.77	(0.21, 2.81)	—
Bourgogne-Franche-Comté	1,706	168	1.00	(0.80, 1.27)	—	0.90	(0.32, 2.52)	—	141	0.91	(0.67, 1.24)	—	0.58	(0.13, 2.54)	—	20	1.34	(0.95, 1.88)	—	2.16	(0.63, 7.38)	—
Centre-Val-de-Loire	1,615	156	1.09	(0.82, 1.45)	—	1.33	(0.56, 3.14)	—	132	1.15	(0.86, 1.52)	—	1.57	(0.67, 3.66)	—	—	—	—	—	—	—	—
Grand Est	3,381	337	1.12	(0.99, 1.28)	—	1.08	(0.67, 1.73)	—	291	1.15	(1.00, 1.31)	—	1.17	(0.73, 1.87)	—	—	—	—	—	—	—	—
Pays de la Loire	2,447	206	1.24	(1.07, 1.42)	—	1.76	(1.16, 2.67)	—	180	1.21	(1.03, 1.42)	—	1.82	(1.18, 2.81)	—	—	—	—	—	—	—	—

Note: —, no data; CI, confidence interval; CLC, Corine Land Cover; OR, odds ratio; PACA, Provence-Alpes-Côte d’Azur; RPG, Graphic Parcel Register.

^{^a}

OR for a 10% increase in viticulture density and its 95% CI estimated by unconditional logistic regression adjusted for age.

^{^b}

p-value of the test for heterogeneity between regions (test for an interaction between viticulture density and region).

^{^c}

The analyses could not be carried out in the Hauts-de-France, Île-de-France, Normandie, and Bretagne regions due to an insufficient number of children living near the vines.