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. 2023 Sep 28;14(40):11243–11250. doi: 10.1039/d3sc03643j

Substrate scope of red-light-mediated Barton decarboxylative Giese reaction.

graphic file with name d3sc03643j-u5.jpg
Entry Reagent R1 R2 R3 Yield
7 8
1 graphic file with name d3sc03643j-u6.jpg 6a CO2Me H H 67 20
2 graphic file with name d3sc03643j-u7.jpg 6b CO2t-Bu H H 50 22
3 graphic file with name d3sc03643j-u8.jpg 6c COCH3 H H 65 21
4 graphic file with name d3sc03643j-u9.jpg 6d CN H H 55 17
5 graphic file with name d3sc03643j-u10.jpg 6e CO2H H H 78 18
6 graphic file with name d3sc03643j-u11.jpg 6f CO2NPhth H H ND 13
7 graphic file with name d3sc03643j-u12.jpg 6g CO2Me H Me 35 37
8 graphic file with name d3sc03643j-u13.jpg 6h CO2Me Me H ND 65
9 graphic file with name d3sc03643j-u14.jpg 6i CO2Me CO2Me H 50a 17
10 graphic file with name d3sc03643j-u15.jpg 6j CO2Me CO2Me H 30a 66
11 graphic file with name d3sc03643j-u16.jpg 6k graphic file with name d3sc03643j-u17.jpg H ND 54
12 graphic file with name d3sc03643j-u18.jpg 6l graphic file with name d3sc03643j-u19.jpg H ND 68
a

d.r. = 5 : 1.