Substrate scope of red-light-mediated Barton decarboxylative Giese reaction.
| |||||||
|---|---|---|---|---|---|---|---|
| Entry | Reagent | R1 | R2 | R3 | Yield | ||
| 7 | 8 | ||||||
| 1 |
|
6a | CO2Me | H | H | 67 | 20 |
| 2 |
|
6b | CO2t-Bu | H | H | 50 | 22 |
| 3 |
|
6c | COCH3 | H | H | 65 | 21 |
| 4 |
|
6d | CN | H | H | 55 | 17 |
| 5 |
|
6e | CO2H | H | H | 78 | 18 |
| 6 |
|
6f | CO2NPhth | H | H | ND | 13 |
| 7 |
|
6g | CO2Me | H | Me | 35 | 37 |
| 8 |
|
6h | CO2Me | Me | H | ND | 65 |
| 9 |
|
6i | CO2Me | CO2Me | H | 50a | 17 |
| 10 |
|
6j | CO2Me | CO2Me | H | 30a | 66 |
| 11 |
|
6k |
|
H | ND | 54 | |
| 12 |
|
6l |
|
H | ND | 68 | |
d.r. = 5 : 1.