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. 2022 Jul 15;24(4):850–865. doi: 10.1093/biostatistics/kxac024

Table 1.

Analysis of M13 average titer (upper vs. lower tertile) as a CoR and a controlled risk CoP: CYD14 and CYD15 dengue VE trials

  Marginalized risk ratio Inline graphic Controlled risk ratio Inline graphic e(0,1)Inline graphic
Trial Point Est. 95Inline graphic CI Point Est. 95Inline graphic CI Point Est. 95Inline graphic CI UL
CYD14 0.17 0.08–0.29 0.38 0.18–0.66 11.6 6.3
CYD15 0.05 0.02–0.09 0.10 0.04–0.20 43.7 22.0

Inline graphic Conservative (upper bound) estimate assuming unmeasured confounding at level Inline graphic and thus Inline graphic.

Inline graphic E-values are computed for upper tertile Inline graphic vs. lower tertile Inline graphic biomarker subgroups after controlling for age, sex, and country; UL = upper limit of 95Inline graphic confidence interval.