Skip to main content
. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: Front Trop Dis. 2022 Mar 18;3:813671. doi: 10.3389/fitd.2022.813671

TABLE 1 ∣.

Immunogenicity of pMG4020 and V4020 vaccines in rabbits.

Vaccine, route Day 0
 Day 7
 Day 21
Vaccine dose PRNT50/80 Viremia direct, PFU/ml Viremia, by amplification, PFU/ml PRNT80 PRNT50
1. V4020, SC 104 PFU < 10 < 10 < 1 < 10 < 10
2. V4020, TD 104 PFU < 10 < 10 < 1 640 5,120
3. pMG4020, TD 20 μg < 10 < 10 < 1 320 1,280
4. pMG4020, TD 20 μg < 10 < 10 < 1 40 160
5. pMG4020, TD 20 μg < 10 < 10 < 1 640 1,280

Pre-bleed sera (day 0) were used to compare PRNT titers of sera from days 7 and 21 post-vaccination to PRNT titers of pre-bleed. Statistical analysis was performed using mean logarithm of titer (day 21) and one-sided Student’s t-test.

V4020, live-attenuated virus; pMG4020, iDNA plasmid; SC, subcutaneously using syringe; TD, transdermally using 3M (Kindeva) hMTS devices; PRNT, plaque reduction neutralization test.