Table 3.

Variation in AFP, PVT (+), and focality for a single focal number in relation to MTD as categories. All in patients with HCC having AFP ≤200 IU/mL (A) and AFP >200 IU/mL (B).

Interval MTD (cm)	Increase in MTD (cm)a	AFP (IU/mL) (median)	Proportionality factor from the first median value	PVT (+) (%)	Proportionality factor from the first median value	Nodule # (1) (%)	Proportionality factor from the first median value	Nodule # (2) (%)	Proportionality factor from the first median value	Nodule # (≥3) (%)	Proportionality factor from the first median value
(A) AFP ≤ 200 (IU/mL)
≤4.0	Ref.	9.76	–	6.68	–	60.55	–	31.75	–	7.70	–
4.1–6.0	2	11.71	1.20	20.29	3.04	50.04	0.83	35.24	1.11	14.72	1.91
4.1–8.0	4	11.99	1.23	23.33	3.49	46.96	0.78	34.81	1.10	18.23	2.37
4.1–10.0	6	11.80	1.21	26.52	3.97	45.63	0.75	33.35	1.05	21.03	2.73
4.1–12.0	8	11.80	1.21	31.01	4.64	43.51	0.72	30.39	0.96	26.10	3.39
(B) AFP > 200 (IU/mL)
≤4.0	Ref.	875.63	–	23.00	–	45.87	–	35.81	–	18.31	–
4.1–6.0	2	2032.00	2.32	35.55	1.55	32.71	0.71	34.07	0.95	33.22	1.81
4.1–8.0	4	2517.45	2.88	39.74	1.73	34.49	0.75	31.30	0.87	34.20	1.87
4.1–10.0	6	2881.00	3.29	44.66	1.94	34.44	0.75	29.23	0.82	36.34	1.98
4.1–12.0	8	3515.00	4.01	51.07	2.22	30.78	0.67	23.82	0.66	45.40	2.48

Abbreviations: AFP, alpha-fetoprotein; HCC, hepatocellular carcinoma; MTD, maximum tumor diameter; PVT, portal vein thrombosis.

^aIncrease in MTD compared with the reference MTD.

The proportionality factor relates the values of the AFP, PVT (+), and focality for a single focal number corresponding to the category of the tumor size with respect to the value referred to the first category of MTD.

This proportionality factor represents how many times the values of AFP, PVT (+), and focality for single focal number increase with increasing tumor size, compared with the first category of MTD (≤4.0 cm).