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. 2023 Aug 10;14(10):2079–2088. doi: 10.1039/d3md00224a

Inhibition of cPLA2α and FAAH.

graphic file with name d3md00224a-u2.jpg
Comp. R1 R2 n Inhibition of cPLA2α IC50a (μM) Inhibition of FAAH IC50a (μM)
10 H H 2 0.047 0.032
13 CH3 H 2 0.19 0.034
14 H CH3 2 0.18 >10b
15 CH3 H 3 0.50 0.034
16 H CH3 3 0.25 0.75
a

Values are the means of at least two independent determinations, errors are within ±20%.

b

31% Inhibition at 10 μM.