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| Structural insight | Residues in MEK1 | Residues in MEK2 |
|---|---|---|
| αC-helix (N-lobe) | L118 | 122 |
| P-loop/ADP (N-lobe) | 74–82 | 78–86 |
| ATP binding sites | 143–146 | 147–150 |
| Activation segment (C-lobe) | 210–233 | 214–237 |
| Catalytic loop | 191–195 | 196–198 |
| F-helix (C-lobe) | D245/L253/M256 | 249/257/260 |
| D-helix (C-lobe) | L151 | 155 |
| DFG motif | ASP208, PHE209, GLY212 | ASP12, PHE213, GLY214 |
| No. of residues | 393 | 400 |
| Molecular weight (kDa) | 43 kDa | 44 kDa |
