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Recombinant CYP3A4 and CYP2B6 metabolite and glutathione-trapped reactive metabolite screening for NVP and 12-d3-NVP. Representative UV chromatograms (280 nm) for NVP (A, B) and 12-d3-NVP (C, D) incubated at 50 μM for 60 min with recombinant CYP3A4 (A, C) and CYP2B6 (B, D) (100 pmol/mL) in the presence of 1 mM reduced l-glutathione and with or without the cofactor NADPH. IS, internal standard.
